Developing an analysis strategy up front in parallel with experimental design is key to avoiding costly errors down the road.
Alzheimer’s disease is a progressive, debilitating disease that accounts for 60-80% of all dementia cases, however, it remains untreatable. In this blog, we provide an overview of many commonly used organisms for modeling AD, and compare their advantages and limitations.
The nematode Caenorhabditis elegans has provided remarkable insights into the biology of aging. The precisely measurable lifespan of worms has proven to be an efficient tool to assess the impact of various genetic, physiological and environmental factors on organismal aging. Lifespan assays can be labor intensive and time consuming. In this article, we will highlight the critical considerations that could make or break your lifespan assay. Our aim is to help you interpret a variety of different procedures by emphasizing the crucial considerations to ensure the success of running a lifespan assay.
According to the Epilepsy Foundation 1 in 26 people in the U.S.A will develop epilepsy at some point in their life, however, epilepsy is a very diverse condition which makes researching it especially challenging. In this blog, we will discuss the model organisms commonly used in epilepsy research, and how their characteristics act as advantages and limitations when modeling epilepsy.
Model organisms are essential to experimental research, allowing researchers and scientists to address a variety of questions. While no model is perfect, some models are more suitable for investigating specific questions than others. In this blog, we provide an overview of many commonly used model organisms, and compare their advantages and limitations.
Neurological disorders are extremely widespread, affecting over 1 billion people worldwide, and have debilitating effects, impacting the brain, spinal cord, cranial nerves, and peripheral nerves. Despite this, many neurological disorders lack effective treatment. One strategy that offers an attractive way to find better therapies is drug repurposing. Also known as drug reprofiling or drug repositioning, drug repurposing identifies new purposes for pre-existing compounds, and offers reduced time frames, decreased costs, and improved success rates. While drug repurposing for neurological disorders has gained attention in the past decade, it is still an underused approach. In this article we will discuss drug repurposing, its benefits, its place in neurological drug research, and its recent success.