C. elegans MosSCI Service

C. elegans Genome-Editing Services

C. elegans MosSCI Service

The MosSCI service enables you to integrate your desired sequence as a single copy insertion at a designated locus in the C. elegans genome. This is advantageous as it allows you to leave the native gene unmodified. With the MosSCI service you can:

Integrate a humanized gene into the C. elegans genome
Integrate your gene of interest into the genome with a fluorescent tag
Integrate your gene of interest into the genome with an immunotag
Examine your gene of interest’s expression under the control of a different promoter

MosSCI vs. Split hygromycin – which one should you choose? Read the blog >>

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C. elegans MosSCI Service Pricing

Service Package	Price	Est. Delivery Time
Full Build	$4,635	8 weeks and up
Candidate Lines	$2,785	6 weeks and up
Custom Injection Mix	$1,620	4 weeks and up

Note: Additional charge applies for cargo over 4.5kb in size for all packages.

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MosSCI Publications

Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture
Jamie B. Harrisa, Jessica H.Hartman, Anthony L. Luz, Joanna Y. Wilson, Audrey Dinyaria, Joel N.Meyer.Toxicology Volume 440, July 2020, 152473.
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.
Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA. Molecular Therapy Nucleic Acids. 2019 April 15;15: 12-25.
Developmental dynamics of gene expression and alternative polyadenylation in the Caenorhabditis elegans germline.
West SM, Mecenas D, Gutwein M, Aristizábal-Corrales D, Piano F, Gunsalus KC. Genome Biol. 2018 Jan 24;19(1):8.

Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis.
Falcke JM, Bose N, Artyukhin AB, Rödelsperger C, Markov GV, Yim JJ, Grimm D, Claassen MH, Panda O, Baccile JA, Zhang YK, Le HH, Jolic D, Schroeder FC, Sommer RJ. Cell Chem Biol. 2018 Jun 21;25(6):787-796.e12.
Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.
Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE. Nat Commun. 2017 Jun 6;8:15558.
Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?
Carvalho, RN; Arukwe, A; Ait-Aissa, S; Bado-Nilles, A; Balzamo, S; Baun, A; Belkin, S; Blaha, L; Brion, F; Conti, D; Creusot, N; Essig, Y; Ferrero, VE; Flander-Putrle, V; Fürhacker, M; Grillari-Voglauer, R; Hogstrand, C; Jonáš, A; Kharlyngdoh, JB; Loos, R; Lundebye, AK; Modig, C; Olsson, PE; Pillai, S; Polak, N; Potalivo, M; Sanchez, W; Schifferli, A; Schirmer, K; Sforzini, S; Stürzenbaum, SR; Søfteland, L; Turk, V; Viarengo, A; Werner, I; Yagur-Kroll, S; Zounková, R; Lettieri, T. Toxicol Sci. 2014 Sep;141(1):218-33.
Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis
Ding, WY; Ong, HT; Hara, Y; Wongsantichon, J; Toyama, Y; Robinson, RC; Nédélec, F; Zaidel-Bar, R. J Cell Biol. 2017 May 1;216(5):1371-1386.
The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1
Schultz, J; Lee, SJ; Cole, T; Hoang, HD; Vibbert, J; Cottee, PA; Miller, MA; Han, SM. Development. 2017 Jun 15;144(12):2175-2186.
MED GATA factors promote robust development of the C. elegans endoderm
Maduro, MF; Broitman-Maduro, G; Choi, H; Carranza, F; Wu, AC; Rifkin, SA. Dev Biol. 2015 Aug 1;404(1):66-79.
The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein
Wu, JC; Espiritu, EB; Rose, LS. Dev Biol. 2016 Apr 15;412(2):288-297.
Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy
Baruah, PS; Beauchemin, M; Parker, JA; Bertrand, R. PLoS One. 2017 May 8;12(5):e0177413.
Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
Chen, AT; Guo, C;Itani, OA; Budaitis, BG; Williams, TW; Hopkins, CE; McEachin, RC; Pande, M;Grant, AR; Yoshina, S; Mitani, S; Hu, PJ. Genetics. 2015 Oct;201(2):613-29.
Matefin/SUN-1 Phosphorylation on Serine 43 Is Mediated by CDK-1 and Required for Its Localization to Centrosomes and Normal Mitosis in C. elegans Embryos
Zuela, N; Gruenbaum, Y. Cells. 2016 Feb 24;5(1).

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