Drug Toxicity - InVivo Biosystems

Chemicals Models of Parkinson’s Disease in Larval Zebrafish

Disease Modeling, Drug Discovery, Drug Toxicity / By Laura Taggart-Murphy and Alexandra Narin / September 15, 2022 September 15, 2022

Parkinson’s disease [PD] is a progressive, debilitating condition which affects over 10 million people worldwide. Being such an impactful, and costly disease (~$52 billion per year in the USA), researchers have turned to modeling the disease in alternative animal models like the zebrafish (Parkinson’s Foundation, 2018). In this article we discuss how larval zebrafish are …

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Toxicity Screening: A New Generation of Models

Disease Modeling, Drug Toxicity / By Alexandra Narin / July 15, 2021 July 15, 2021

In the age of industries continuously creating and remodeling chemicals, having a reliable way to test their toxicity is vital. At the same time, across all areas of research, there is the desire to shift away from traditional animal models. In this article we outline the New Approach Methods (NAMs) and some of the steps being taken to implement them.

Worms on drugs: How well can C. elegans predict drug toxicity in mammals?

Aging & Healthspan, Drug Toxicity, View from the Bench / By Adam Saunders / September 1, 2020 November 9, 2020

One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.

The Evolution of Drug Resistance; an Issue of “When, not if”

Disease Modeling, Drug Toxicity, View from the Bench / By Janis Weeks, Ph.D. / September 25, 2019 November 10, 2020

Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal health. Resistance is manifested by a decreased ability, or complete failure, of previously-effective drugs to successfully prevent or clear infections. Well-known human examples include methicillin-resistant Staphylococcus aureas (MRSA); multi-drug resistant …

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wMicroTracker Applications: Drug Screening

Drug Discovery, Drug Toxicity, View from the Bench / By Yoanne Clovis, Ph.D. / October 9, 2018 November 10, 2020

The wMicroTracker is a great product to add to your drug screening toolkit. Check out the application sheet below to see how easy it is to use and how it can positively impact your research.