View from the Bench

A short section of pump activity on 5HT vs the pump activity on OP50, both in C. elegans.

E. coli-induced pharyngeal pumping in C. elegans

Kathleen Conery | Pharyngeal pumping behavior in C. elegans is employed to ingest bacteria, the worms’ normal food. Under laboratory conditions, C. elegans are reared on agar plates seeded with the E. coli strain OP50, which stimulates feeding behavior. Accordingly, we tested the ability of OP50 treatment to elicit pharyngeal pumping, using the ScreenChip system.

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A bar graph showing C. elegans EPG rate with and without fennel treatment. Example EPG waveforms are displayed for both populations.

Effect of Fennel Essential Oil on Pharyngeal Pumping in C. elegans

Kathleen Conery | Most existing anthelmintics act on ion channels or neurotransmitter receptors, so determining whether a candidate compound impairs electrical signaling is useful to know early in the screening process. Essential oil of fennel (Foeniculum vulgare) has been used traditionally in South America as a worming agent against human infections with the trematode parasite, Schistosoma mansoni. Using the ScreenChip platform, we investigated the effect of fennel essential oil as an anthelmintic on C. elegans.

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