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Aging & Healthspan

Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?

Summary: Humans have been interested in extending our lifespans for centuries, from quests to find the fountain of youth, to Alchemists attempting to determine the formulation for the elixir of life potion, to modern-day dietitians recommending a calorie-restriction and fasting. However, with the advancement of technology researchers are getting a better picture of how, and …

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What controls your behavior? Your brain or your gut?

Summary: Over the past decade the microbiome has become known as an important modulator of human health, and research in the field has skyrocketed: publications have risen over 6.2x and clinical trials are up 2.9x. One of the most intriguing areas of research is looking at the link between the microbiome and behavior. While many …

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[Press Release] InVivo Biosystems and Thaena Announce Novel Metabolite Research Platform With Compelling Longevity and Healthspan Implications and Outcomes

– Mikra patent focusing on novel cellular therapeutic targeting systemic fatigue
– Mikra partners with InVivo Biosystems for pre-clinical trials to strengthen patent application and generate further data confirming expression pathways for genes

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Testing the efficacy of JadeAging®, a Chinese Medicine based longevity formulation, using InVivo Biosystems’ suite of in vivo platforms

Recently, we have decided to partner with Chenland Nutritionals, Inc., utilizing our suite of in vivo platforms to test the efficacy of their longevity product, JadeAging®. Based on Traditional Chinese Medicine, the formula’s active ingredients are naturally derived: Rehmanniae Radix, Poriae, and Ginseng Radix. In this experiment we will focus on lifespan, healthspan, and transcriptional changes related to aging, and we will document all of it — this article will be the first in a blog-along series where we will walk through our experimental process. So let’s get started!

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From ED to AD: a drug repurposing success? How a performance-enhancing drug is giving insight into dementia

Recently, researchers at Cleveland Clinic’s Genomic Medicine Institute published an article in Nature Aging which has caused quite a stir in the medical community and media – in the article these researchers report that an analysis of over 7 million people, spanning six years, found that those taking the Erectile dysfunction (ED) drug sildenafil (marketed as Viagra) were 69% less likely to develop Alzheimer’s disease (AD). This being said, there are some important caveats to this study – and so, although media reports on this study include lines such as “the little blue pill could soon be prescribed to tackle dementia”, more realistic implications should be the takeaway (but not less exciting!).

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The Argument for Aging as a Disease

When asked how someone died, ‘they died of old age’ is an acceptable answer – it is given as the cause, like a heart attack, stroke, or cancer. However, unlike these other answers, aging is not classified as a disease. But should it be? This article will discuss the debate over whether aging should be considered a disease, the arguments for and against such a classification, what it would mean from a clinical standpoint, and how it would transform the pharmaceutical and nutraceutical industries.

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