How does Cre/loxP recombination work?
In this blog, we discuss the basics of the Cre/Lox technique which is used in conditionally controlling gene manipulation in zebrafish.
One Fish in a Large Pond: History of the Zebrafish and Other Fish Models for Research Applications
This article reviews the history of the zebrafish, and discusses the scenarios when other fish species are advantageous.
What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part
The Undiagnosed Diseases Network UND is a nationwide network that is working to understand and diagnose rare and undiagnosed human diseases. The UND coordinates between research and clinical experts, using the latest genetic and genomic technologies to create a more personalized medicine model.
From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network
The Undiagnosed Diseases Network brings together experts across the USA, combining clinical care and research to find diagnoses for undiagnosed patients. Zebrafish are extremely valuable disease models in this research, as they reduce the cost and speed up the process of identifying therapeutic targets. In this blog we highlight one rare disease whose mechanism was successfully identified using zebrafish.
Egg Viability Assay – A View From The Bench
The main purpose of this assay is to find the potential humanized LMNA worm variants that have a fecundity defect.
Zebrafish Genome Editing: CRISPR vs. Tol2
One of our scientists compares two popular genome editing tools, CRISPR and Tol2 to better understand the pros and cons of each technology
Why Validating Your Plasmids is Key to a Successful Transgenic, and How You Can Do It Too.
Plasmids are a key tool in molecular biology. These circular pieces of DNA, also called “vectors” or “constructs”, can be engineered to contain large made-to-order stretches of synthetic DNA. We design plasmids when we need to insert large stretches of synthetic DNA into the genome to create a model organism expressing, for instance, a fluorescent …