How does Cre/loxP recombination work?
In this blog, we discuss the basics of the Cre/Lox technique which is used in conditionally controlling gene manipulation in zebrafish.
Validating Expression of Humanizations – What We’ve Done so Far
In an effort to create better research models for epilepsy, we’ve been working on a grant-funded project to humanize numerous C. elegans genes. Learn more about our progress and our findings in this blog.
Problem Solved: Using a new technique to solve a problem
Two main lessons learned: 1. stay current with a broad variety of literature and 2. always be willing to try new methods
Research Spotlight: Summer Sun Safety Month
C. elegans and Zebrafish have been used to study the effects of ultraviolet radiation (UVR) for decades. August is Summer Sun Safety Month so in this month’s Research Spotlight we wanted to highlight sun safety and how C. elegans and zebrafish are helping in this field.
A View From the Bench: Roadblocks and Frustrations When Expectation Meets Reality.
In an effort to create better models for epilepsy, we’ve been working on a grant-funded project to humanize important synaptic machinery by replacing endogenous coding sequences with human coding sequences. Syntaxin is a key synaptic protein, encoded by the gene STX1A, that helps synaptic vesicles dock, fuse with the membrane, and release neurotransmitters. Syntaxin has …
A View From the Bench: Roadblocks and Frustrations When Expectation Meets Reality. Read More »