C. elegans Behavior & Phenotyping
Measuring Metal Toxicity
Used for whole-animal toxicology and safety testing to quantify adverse effects of chemical substances (e.g., environmental pollutants, drugs) on living organisms.
Measuring metal toxicity. Red fluorescence is induced in animals exposed to Cadmium.
APPLICATIONS
Can be used to study toxic effects on whole organisms and uncover gene/environment interactions. Performing tests on C. elegans reduces the use of mammals in toxicology testing.
ASSAY DESCRIPTION
The exposure to cadmium, lead, and other toxic metals induces a fluorescent response in the biosensor C. elegans.
DATA COLLECTED
Environmental samples are tested and the fluorescence intensity is measured using a population of worms. Worm number is normalized by using a constitutively expressed GFP.
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