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Disease Modeling

Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?

Summary: Humans have been interested in extending our lifespans for centuries, from quests to find the fountain of youth, to Alchemists attempting to determine the formulation for the elixir of life potion, to modern-day dietitians recommending a calorie-restriction and fasting. However, with the advancement of technology researchers are getting a better picture of how, and …

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Chemicals Models of Parkinson’s Disease in Larval Zebrafish

Parkinson’s disease [PD] is a progressive, debilitating condition which affects over 10 million people worldwide. Being such an impactful, and costly disease (~$52 billion per year in the USA), researchers have turned to modeling the disease in alternative animal models like the zebrafish (Parkinson’s Foundation, 2018). In this article we discuss how larval zebrafish are …

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Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants

We have previously discussed how the advancement of genomics technology has led to an increase in variants of unknown significance (VUS), and how important it is to identify whether or not they are disease-causing. In this review we discuss a recent publication from Dr. Oliver Blacque and collaborators (Lange et al., 2022), where they leveraged …

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Using Zebrafish as a Model for Opioid Addiction with Dr. Gabriel Bossé (University of Utah)

In Episode 67 of 17 Minutes of Science, we are joined by Dr. Gabriel Bossé. Gabriel Bossé is currently a postdoctoral fellow with Randall Peterson at the University of Utah. Listen in as we talk with Gabriel on how he developed the first self administration model using zebrafish to study opioid addiction.

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A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties

Summary Inflammation’s role in diseases has become increasingly apparent, with inflammatory responses being linked to diseases as common as arthritis, and as debilitating as Parkinson’s. A promising way to counteract inflammation is through natural compounds – currently these compounds are being tested on the well-suited alternative animal model, zebrafish. In this article we discuss the …

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Temperature & C. elegans Part Two: How does Temperature affect development?

Summary: We recently published a piece on the importance of temperature in C.elegans which got the whole InVivio Biosystems team thinking about C. elegans’ development, and how it can best be compared. As a result, we thought it would be fun to take pictures of C. elegans in the three most commonly used temperatures to …

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