Summary Drug repurposing takes previously known compounds and drugs, and applies them to current health problems. Drug repurposing is particularly beneficial for finding rare disease therapies because it offers an accelerated and economical alternative to traditional drug discovery, a process which is often deemed too costly and time consuming for the small population pools affected …
The Western Medical Community has long viewed acupuncture with skepticism, but increasingly physicians are exploring the potential benefits of this traditional practice. In fact, despite often being referred to as a pseudoscience, recent research has found significant benefits of acupuncture treatment for patients with chronic pain and those suffering from opioid addiction. In this article …
Poking its way into Western Medicine: How Acupuncture Could Help Ease Chronic Pain Read More »
Summary: This Earth Month we at InVivo Biosystems are thinking about how we utilize Earth’s resources in biomedicine – from animal systems that enable us to model a patient’s disease or gene mutation, to natural products which can act as therapeutics, we have a lot to be grateful for. Often when thinking about celebrating Earth …
Quick Guide to Natural Products: What They are and How They Impact You Read More »
Neurological disorders are extremely widespread, affecting over 1 billion people worldwide, and have debilitating effects, impacting the brain, spinal cord, cranial nerves, and peripheral nerves. Despite this, many neurological disorders lack effective treatment. One strategy that offers an attractive way to find better therapies is drug repurposing. Also known as drug reprofiling or drug repositioning, drug repurposing identifies new purposes for pre-existing compounds, and offers reduced time frames, decreased costs, and improved success rates. While drug repurposing for neurological disorders has gained attention in the past decade, it is still an underused approach. In this article we will discuss drug repurposing, its benefits, its place in neurological drug research, and its recent success.
We use the zebrafish (Danio rerio) as an in vivo model to measure the functional effects of patient-derived genetic variation. In this way, human genetic variants identified in the clinic are quantitatively and qualitatively connected to model animal phenotypes. As a proof of concept study, we used precision gene editing and transient knockdown approaches targeting stxbp1a – the …
